BMS 599626 dihydrochloride is a potent and selective EGFR and ErbB2 inhibitor. BMS-599626 inhibited HER4 (IC50: 190 nM). In Sal2, N87, and GEO tumor cells, BMS-599626 inhibited phosphorylation of HER1 and HER2 in a dose-dependent way and inhibited cell proliferation. In AU565 breast cancer cells, BMS-599626 (1μM) inhibited HER1/HER2 heterodimer formation. In tumor cells that forming HER1/HER2 heterodimers, BMS-599626 inhibited heterodimerization [1][2].

In the L2987 human lung tumors xenograft models, BMS-599626 (60 mg/kg) inhibited and delayed tumor growth in a dose-dependent way [1].

T22610

C27H27FN8O3·2HCl

603.48

BMS 599626 dihydrochloride;BMS 599626 dihydrochloride (714971-09-2 free base)

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years