Harmaline hydrochloride 是一种荧光吲哚生物碱，来自 harmala 生物碱和 β-咔啉。它是 harmine 的部分氢化形式。 Harmaline 通过诱导下橄榄神经元的节律性放电在正常大鼠中产生全身性震颤。

Harmaline hydrochloride is a fluorescent indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmine.Harmaline produces a generalized tremor in normal rats by inducing rhythmic firing of inferior olivary neurons

Harmaline could up-regulate the expressions of cell cycle-related proteins of p-Cdc2, p21, p-p53, Cyclin B and down-regulate the expression of p-Cdc25C. In addition, Harmaline could up-regulate the expressions of Fas/FasL, activate Caspase-8 and Caspase-3[1].

Harmaline could exert on antitumor activity with a dose of 15?mg/kg/day in vivo, which is related with cell cycle arrest.Harmaline also induces cognitive disturbances such as motor and spatial learning impairments. Lower doses of harmaline (5–10 mg/kg) have anxiogenic effects since higher doses (20 mg/kg) have anxiolytic-like properties[1].

363-11-1

C13H15ClN2O

250.73

Harmidine hydrochloride;Harmaline hydrochloride

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years