7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the NMDA receptor (IC50: 0.56 μM). It is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles (Ki: 0.59 μM).

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid sodium salt (10 nM) shows significant retardation of the development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response [3].

1263094-00-3

C10H6ClNNaO3

246.6

7-CKA sodium salt;7-Chlorokynurenic acid sodium salt

H2O:50 mg/mL (203.59 mM),Need ultrasonic
DMSO:33.67 mg/mL (137.10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years