CGP 78608 hydrochloride is a highly selective antagonist at the glycine binding site of the NMDA receptor (IC50: 6 nM). CGP 78608 acts as a potentiator of GluN1/GluN3A-mediated glycine currents (estimated EC50: 26.3 nM).

CGP 78608 hydrochloride reduces or abolishes ammonia-dependent cGMP synthesis which is a causative factor of ammonia neurotoxicity [3]. CGP-78608 hydrochloride decreases glycine sensitivity of GluN1/GluN3A receptors through an inter-subunit allosteric effect between GluN1 and GluN3A agonist-binding domain sites [2].

CGP-78608 (i.p.) displays potent anticonvulsant effects in the electroshock-induced convulsions assay in mice [1].

1135278-54-4

C11H14BrClN3O5P

414.58

CGP 78608 hydrochloride

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years