MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a K i value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent.

MK-6884 (compound 13; 0-22 μM) is a PAM of ACh function in a cell-based Ca 2+ mobilization assay, with an EC 50 of 27 nM[1].

[ 11 C]MK-6884 (compound 13) shows non-displaceable binding potential (BP ND ) of 0.83 in rhesus monkeys[1]. [ 11 C]MK-6884 (approximately 185 MBq,<2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain[1]. [ 11 C]MK-688 can penetrate the blood-brain barrier in monkeys[1].

2102194-04-5

C25H25N5O

411.509

MK-6884

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years