nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4) 3 (β2) 2 nAChR to ACh (10 μM) with an EC 50 of 0.26 μM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.

CMPI (0.01-10 μM) potentiates (α4) 3 (β2) 2 (low ACh sensitivity) but not (α4) 2 (β2) 3 (high ACh sensitivity) nAChRs in Xenopus laevis oocytes[1]. CMPI (0.01-10 μM) inhibits (α4) 2 (β2) 3 , human muscle and Torpedo nAChRs with IC 50 s of 0.6, 0.7 and 0.2 μM, respectively in Xenopus oocytes[1].

2250025-94-4

C18H20Cl2N4O

379.29

nAChR agonist CMPI hydrochloride

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years