MMG-11 quarterhydrate 是一种有效的选择性人TLR2拮抗剂。MMG-11 quarterhydrate 抑制 TLR2/1 和 TLR2/6 信号转导，抑制 Pam3CSK4诱导的 hTLR2/1，IC50为 1.7 μM，抑制 Pam2CSK4诱导的 hTLR2/6 反应，IC50为 5.7 μM。

MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC 50 s of 1.7 μM for Pam 3 CSK 4 -induced hTLR2/1 and 5.7 μM for Pam 2 CSK 4 -induced hTLR2/6 responses [1].

MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 μM) shows no cytotoxic effects up to 100 μM in peripheral blood mononuclear cells (PBMCs) [1]. Cell Cytotoxicity Assay [1] Cell Line: PBMCs Concentration: 0.01, 1, 10, 100 μM Incubation Time: Result: Showed no cytotoxic effects up to 100 μM.

C15H16O8

310.78

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years