Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

1804978-82-2

C33H39Cl2N5O5S

688.67

YNT-185 dihydrochloride

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years