CNQX 是一种竞争性、非 NMDA 谷氨酸受体拮抗剂，对 AMPA 和红藻氨酸受体的IC50分别为 0.3 和 1.5 μM。

CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)

In rat hippocampal slices bathed in Mg2+-free medium 10 microM CNQX reversibly blocks responses to alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), quisqualate and kainate but not NMDA. The synaptic response evoked by low frequency stimulation of Schaffer collateral-commissural fibres in 1 mM Mg2+-containing medium is completely blocked by this concentration of CNQX. In contrast the synaptic response evoked in Mg2+-free medium is not fully blocked by CNQX[1].

115066-14-3

C9H4N4O4

232.155

FG9065;6-氰基-7-硝基喹喔啉-2,3-二酮;CNQX

DMSO:30 mg/mL (129.23 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years