Risperidone hydrochloride (R 64 766 hydrochloride) 是5-HT2受体的阻断剂，P-糖蛋白(P-Glycoprotein)的抑制剂 和dopamine D2受体的拮抗剂，其对 5-HT2A和 dopamine D2受体的Ki值分别为 4.8，5.9 nM。

Risperidone hydrochloride (R 64 766 hydrochloride) 5-HT 2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D 2 receptor antagonist, with K i s of 4.8, 5.9 nM for 5-HT 2A and dopamine D 2 receptor, respectively.

Risperidone is a serotonin 5-HT 2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D 2 receptor antagonist, with K i s of 4.8, 5.9 nM for 5-HT 2A and dopamine D 2 receptor, respectively. Risperidone dose-dependently inhibited the release of IL-12 in mature DCs, while the production of IL-10 is dose-dependently increased by Risperidone. A high dose of risperidone can induce TNF-α release from mature DCs [3].

In the first experiment, body weight is found to be slightly but significantly lower in the Risperidone-treated rats as a function of age. Similar to the first experiment, age-dependent differences in body weight are also observed between the three treatment groups in the second locomotor experiment. Rats treated with the 3.0 mg/kg dose of Risperidone weigh less than vehicle-treated rats on postnatal days 35, 38, and 41. The third locomotor experiment involves larger, mixed-sex litters in contrast to the smaller, single-sex litters used in the first two experiments. As noted for the first two experiments, rats treated with Risperidone in the third experiment gain less weight in an age-dependent manner [4].

666179-74-4

C23H28ClFN4O2

446.95

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years