Anticancer agent 64 (化合物 5m) 对 CCRF-CEM 细胞具有细胞毒性，其IC50为2.4 μM。Anticancer agent 64 通过诱导细胞凋亡表现出良好的抗癌活性。Anticancer agent 64 诱导 Caspase 3 和 7 的激活和 PARP 的裂解。Anticancer agent 64 具有明显的线粒体去极化作用。

Anticancer agent 64 (compound 5m) shows cytotoxic activity in CCRF-CEM cells, with IC 50 of 2.4 μM. Anticancer agent 64 shows good anticancer activity through apoptosis induction. Anticancer agent 64 induces caspase 3 and 7 activation and PARP cleavage. Anticancer agent 64 induces significant effect of mitochondria depolarization [1].

Anticancer agent 64 (compound 5m) increases BAX expression and decreases Bcl-2 protein expression [1].. Anticancer agent 64 shows significant increasement in cells accumulation in the G2/M phase of the cell cycle, while proportion of cells in S phase is reduced [1].

C31H46N2O2S

510.77

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years