1-Dodecylimidazole 是溶酶体活性洗涤剂。1-Dodecylimidazole通过在溶酶体中的酸依赖性积累、溶酶体膜的破坏和半胱氨酸蛋白酶释放到细胞质中而导致细胞死亡。它显示出降胆固醇和广谱抗真菌活性。

1-Dodecylimidazole (N-Dodecylimidazole) is a cytotoxic agent and a lysosomotropic detergent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity.

N-dodecylimidazole is an acid-activated detergent with a pKa of 6.3 which has been shown to be cytotoxic to cells in culture. N-dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose-dependent and was 100-fold greater at pHe 6.0 than pHe 7.0[4].

The hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase[2].1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) has lower serum cholesterol concentrations than control rats[2].

4303-67-7

C15H28N2

236.4

1-Dodecylimidazole

DMSO:100 mg/mL (423.01 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years