Vecuronium bromide 是一种合成的中效单季铵盐类固醇和非去极化神经肌肉阻滞剂，具有肌肉松弛活性。

Vecuronium is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle relaxant activity.

Vecuronium inhibits both forms of the muscle-type acetylcholine receptor (IC50: 1-2 nM). Vecuronium combined with methylprednisolone shows additive effects on both receptor forms.[1] Vecuronium interferes with nicotinic processes in the carotid body and inhibits the chemoreceptor neural response to hypoxia. Vecuronium significantly attenuates the increase in CSNA (DeltaCSNA) in response to hypoxia in the carotid body.[2]

Vecuronium has a higher biliary clearance than pancuronium in the rats.[3]

50700-72-6

C34H57BrN2O4

637.73

ORG NC 45;维库溴铵;Vecuronium bromide

H2O:4 mg/mL (6.27 mM)
Ethanol:93 mg/mL (145.8 mM)
DMSO:93 mg/mL (145.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years