Methylbenactyzium Bromide 是毒蕈碱性乙酰胆碱受体抑制剂，是一种抗惊厥药。

Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.

TW-37 targets the BH3-binding groove in Bcl-2 where proapoptotic Bcl-2 proteins bind, and shows higher affinity and selectivity for Bcl-2 and Mcl-1 over Bcl-xL with Ki values of 0.29 μM, 0.26 μM and 1.11 μM, respectively. [1] In vitro, TW-37 shows significant anti-proliferative and pro-apoptotic effect in a de novo chemo-resistant WSU-DLCL2 lymphoma cell line and primary cells obtained from a lymphoma patient without effects on normal peripheral blood lymphocytes. [1] TW-37 exhibits the inhibitory effect on both cell growth and cell death in endothelial cell with IC50 of approximately 1.8 μM without effect on the fibroblasts exposed to the same concentration range as the endothelial cells. In addition, TW37 also shows the anti-proliferation effects in MCF-7, LNCaP, and SLK tumor cell lines with the same or lower concentration range than those required to inhibit endothelial cell growth. [2]

3166-62-9

C21H28BrNO3

422.36

Noinarin;溴甲贝那替秦;Gastrimade;Methylbenactyzine Bromide;Semulgin;Paragone;Methylbenactyzium Bromide

DMSO:6 mg/mL (14.21 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years