BMT-145027 是一种 mGluR5 的正变构调节剂，没有内在的激动剂活性 (EC50 = 47 nM)。

BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).

BMT-145027 lacks inherent mGluR5 agonist activity when tested at concentrations up to 16 μM. BMT-145027 exhibits high MsLM stability (85% remaining) and a modest decrease in planarity (Fsp3 = 0.17)[1].

BMT-145027 (30 mg/kg) leads to a significant increase in time spent with the novel object, with an apparent trend in novel object preference at 10 mg/kg. Satellite animals(BMT-145027: 30 mg/kg) indicates a total plasma concentration of 2800 nM[1].

2018282-44-3

C23H14ClF3N4

438.83

BMT-145027

DMSO:2.4 mg/mL (5.47 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years