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Revefenacin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Revefenacin图片
CAS NO:864750-70-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
GSK1160724
TD-4208
产品介绍
Revefenacin 是一种mAChR拮抗剂,在M3受体上具有高亲和力,Ki值为 0.18 nM。

产品描述

Revefenacin is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.

体内活性

In anesthetized dogs, TD-4208, along with tiotropium and glycopyrronium, produced sustained inhibition of acetylcholine-induced bronchoconstriction for up to 24 hours. In anesthetized rats, inhaled TD-4208 exhibited dose-dependent 24-hour bronchoprotection against methacholine-induced bronchoconstriction. The estimated 24-hour potency (expressed as concentration of dosing solution) was 45.0 μg/ml[1].

Cas No.

864750-70-9

分子式

C35H43N5O4

分子量

597.76

别名

GSK1160724;TD-4208;Revefenacin

储存和溶解度

DMSO:125 mg/mL (209.12 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years