High affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax< 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.

753499-14-8

C19H20ClF3N2O2

400.82

NS 6740

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years