Potent EGFR Degrader (DC50 values are 39.2 nM for wild-type EGFR in OVCAR8 cells and 736 nM for Exon20Ins mutated EGFR in HeLa cells). Also degrades HER2. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Inhibits proliferation of HER2-driven breast cancer cell lines (IC50 = 102 nM for SKBr3 cells).

2230821-38-0

C55H57ClFN7O8S

1030.61

SJF 1528

DMSO:103.06 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years