Selective EGFR Degrader. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Exhibits selectivity for EGFR, including mutant forms, over HER2. Induces degradation of EGFR in OVCAR8 cells.

2230821-40-4

C57H61ClFN7O9S

1074.66

SJF 1521

DMSO:107.47 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years