ROC-0929 (compound 13a) is a potent and selective inhibitor of secreted phospholipases A 2 (sPLA 2 s) with an IC 50 of 80 nM, specially targeting hGX . ROC-0929 inhibits the phosphorylation of ERK1/2 and p-38 . Secreted phospholipases A2 (sPLA2s) are a family of disulfide-rich, Ca 2+ -dependent enzymes that hydrolyze the sn-2 position of glycero-phospholipids to release a fatty acid and a lysophospholipid. ROC-0929 has the potential for researching inflammation related diseases.

1048660-43-0

C30H31N3O6S

561.65

ROC-0929

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years