IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I in low nM range. IACS-10759 shows significant efficacy in multiple tumor indications both in vitro and in vivo.

1807523-99-4

C25H26ClF3N6O4S

599.03

IACS 10759;IACS-010759;IACS-010759 HCl;IACS-10759;IACS10759;IACS-010759 hydrochloride

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years