WEHI-539 hydrochloride is a selective Bcl-XL inhibitor (IC50: 1.1 nM).

WEHI-539 hydrochloride is a selective Bcl-XL inhibitor. WEHI-539 augments NSC 241240 induced caspase 3/7 activity, PARP cleavage and annexin V labelling. WEHI-539 as a single agent causes noticeable PARP cleavage in Ovcar-4 (5 μM in Ovcar-4.) and Ovsaho (1 μM in Ovsaho) cells[2].

2070018-33-4

C31H30ClN5O3S2

620.19

WEHI-539 hydrochloride

DMSO:50 mg/mL (80.62 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years