(S,R,S)-AHPC-Me hydrochloride 是基于 (S,R,S)-AHPC 的 VHL 配体，可用于募集 von Hippel-Lindau (VHL) 蛋白，用于 ARV-771 的合成。

(S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50<1 nM. (S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

1948273-03-7

C23H33ClN4O3S

481.05

VHL ligand 2 hydrochloride;E3 ligase Ligand 1;(S,R,S)-AHPC-Me hydrochloride

DMSO:62 mg/mL(128.88 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years