您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > MCTR2
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
MCTR2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MCTR2图片
CAS NO:1784701-62-7
包装:1 mg
市场价:-1元

产品介绍

产品描述

Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid in macrophages at the site of inflammation. DHA is oxidized to maresin 1 , which is converted to MCTR1 by glutathione S-transferase Mu 4 or leukotriene C4 synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD2 and PGF2α in the exudate.

Cas No.

1784701-62-7

分子式

C27H40N2O6S

分子量

520.69

别名

MCTR2;MCTR2

储存和溶解度

Ethanol:1 mg/mL
Ethanol:H2O (95:5):2 mg/mL
PBS (pH 7.2):100 μg/mL
DMF:50 mg/mL
DMSO:50 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years