您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > CMLD012612
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CMLD012612
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CMLD012612图片
CAS NO:2368900-35-8
包装与价格:
包装价格(元)
1 mg电议
5 mg电议

产品介绍

产品描述

CMLD012612 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits cell translation and is cytotoxic to NIH/3T3 cells (IC50: 2 nM).

体外活性

The primary mechanism of action of CMLD012612 is dependent on eIF4A1 since eIF4A1em1jp cells are at least 10-fold more resistant than parental NIH/3T3 cells. The sensitivity of eIF4A1em1jp cells to CMLD012612 observed at higher concentrations may be due to the presence of wild-type eIF4A2 in the cells.

体内活性

When administered to mice bearing myr-Akt/Em-Myc lymphomas, CMLD012612 (0.2 mg/kg; i.p.; daily; for 5 days; female C57BL/6 mice) treatment effectively synergizes with Doxorubicin, leading to complete tumor loss. CMLD012612 (0.5 mg/kg; i.p.; for 3 hours; female C57BL/6 mice) treatment effectively suppresses liver polysomes 3 hours after injection.

Cas No.

2368900-35-8

分子式

C31H33N3O7

分子量

559.61

别名

CMLD012612

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years