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ZSET1446
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ZSET1446图片
CAS NO:887603-94-3
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
ST-101
ZSET-1446
产品介绍
ZSET 1446 是一种 T 型钙通道激活剂,用于治疗各类阿尔茨海默病 (AD) 模型中的学习缺陷。

产品描述

ZSET-1446 is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.

体内活性

ZSET1446 ameliorated cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test.?ZSET1446 also reduced grading scores of SAMP8 after 16 weeks of treatment.?Further, 8-week treatment of ZSET1446 significantly reduced the total number of Aβ-positive granules in the hippocampus.?ZSET1446 shows ameliorating effects on SAMP8 partly due to the suppression of an increase of Aβ-deposition in the hippocampus[1].

动物实验

ZSET1446 was administered in drinking water at estimated doses of 0.002, 0.01, and 0.1 mg/kg per day from the age of 8 months mouse.?The SAMP8 at the age of 8 months showed cognitive impairment in a novel object recognition task compared with young SAMP8 at the age of 8 weeks.?Further, grading scores were gradually increased from 9 to 12 months and Aβ-like immunoreactivity in the hippocampus was increased at the age of 10 months[1].

Cas No.

887603-94-3

分子式

C15H12N2O

分子量

236.274

别名

ST-101;ZSET-1446;ZSET1446

储存和溶解度

DMSO:29 mg/ml(122.74 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years