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Biapenem
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Biapenem图片
CAS NO:120410-24-4
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
100 mg电议

产品名称
比阿培南
LJC 10627
Omegacin
CLI 86815
Biapenern
L 627
产品介绍
Biapenem是不经肠道的广谱碳青霉烯抗生素。

产品描述

Biapenem is a 1-beta-methylcarbapenem antibiotic with a wide range of antibacterial activity. Biapenem has similar antibacterial activity to that of imipenem, but is more stable against human renal dehydropeptidase-I and with less neurotoxicity.

体外活性

Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. Biapenem is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. Biapenem is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested. [1] Biapenem shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates. [2] Biapenem is found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates. [3]

体内活性

Biapenem results in significantly fewer viable bacteria than in the lungs of control mice. Biapenem prevents the progression of lung inflammation, including alveolar neutrophil infiltration and hemorrhage. Biapenem significantly prolongs survival and reduces the number of viable bacteria in a murine model of VAP caused by P. aeruginosa. [4]

Cas No.

120410-24-4

分子式

C15H18N4O4S

分子量

350.39

别名

比阿培南;LJC 10627;Omegacin;CLI 86815;Biapenern;L 627;Biapenem

储存和溶解度

DMSO:Insoluble
H2O:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years