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Necrostatin 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Necrostatin 2图片
CAS NO:852391-19-6
包装:100 mg
市场价:8388元

产品介绍

产品描述

Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.

体外活性

Necrostatin 2 displays activity in a broad range of necroptosis cellular systems[1]. Necrostatin 2 at 30 μM fully protects L929 cells from TNF-α-induced necroptosis. In addition to TNF-α, the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD.fmk) has also been found to induce necrosis in L929 cells, which is efficiently inhibited by Necrostatin 2[2]. Evaluation of necroptosis inhibitory activity is performed using a FADD-deficient variant of human Jurkat T cells treated with TNF-α. Utilizing these conditions the cells efficiently undergo necroptosis, which is completely and selectively inhibited by Necrostatin 2 (EC50=50 nM). EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM[3].

Cas No.

852391-19-6

分子式

C13H12ClN3O2

分子量

277.71

别名

Necrostatin 2

储存和溶解度

DMSO:100 mg/mL (360.09 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years