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GSK2593074A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK2593074A图片
CAS NO:1337531-06-2
包装与价格:
包装价格(元)
50 mg电议
100 mg电议

产品名称
GSK'074
产品介绍

产品描述

GSK2593074A is a necroptosis inhibitor for dual-targeting to both RIP1 and RIP3.

体外活性

In multiple cell types including mouse SMCs, fibroblasts (L929), bone marrow derived macrophages (BMDM), and human colon epithelial cells (HT29), GSK2593074A inhibits necroptosis with an IC50 of ~3?nM.GSK2593074A (GSK'074; 0.01, 0.1, 1, 10, and 100 nM; 6?hours for MOVAS cells; 3 hours for L929 cells) completely rescues cells from necroptosis under different stimuli in both human and murine cells at IC50~3?nM.

体内活性

GSK2593074A significantly decreases the extent of aortic expansion.GSK2593074A ?is administrated to Apoe-/- mice immediately following pump implantation. Compared to the DMSO group, GSK2593074A-treated mice show significantly alleviated aneurysm formation, reflected by a much smaller aortic dilatation as well as a reduced abdominal aortic aneurysm ?incidence (from 83.3 to 16.7%).

Cas No.

1337531-06-2

分子式

C27H23N5OS

分子量

465.57

别名

GSK'074;GSK2593074A

储存和溶解度

DMSO:41.67 mg/mL (89.50 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years