Dobutamine hydrochloride 是一种合成的儿茶酚胺，可作用于肾上腺素能受体α1-AR、β1-AR和β2-AR，是一种选择性的 β1-AR 受体激动剂，对 α1-AR 和 β2-AR 作用相对较弱。它能够增加心输出量，矫正低灌注。

Dobutamine (hydrochloride) is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects.

In wildtype mice increasing doses of dobutamine resulted in subsequent increase in the left ventricular function and heart rate acceleration, but significant inotropic, lusitropic, and chronotropic cardiac response was observed only after high doses of dobutamine.

Animal Model:Tgαq*44 mice (heart failure models). Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose. Administration:Intraperitoneal injection

49745-95-1

C18H24ClNO3

337.84

Dobutamine (hydrochloride);盐酸多巴酚丁胺;Dobutamine hydrochloride

H2O:20 mg/mL (59.20 mM),Need ultrasonic
DMSO:33 mg/mL (97.68 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years