Thalidomide-O-amido-C6-NH2 TFA 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物。可用于 PROTAC 的合成分子。

Thalidomide-O-amido-C6-NH2 TFA, a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.

PROTACs contain two different ligands connected by a linker; one of them is a ligand for an E3 ubiquitin ligase and the other one is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

1950635-14-9

C23H27F3N4O8

544.48

Cereblon Ligand-Linker Conjugates 11 TFA;E3 Ligase Ligand-Linker Conjugates 25 TFA;E3 Ligase Ligand-Linker Conjugates 25 Trifluoroacetate;Thalidomide-O-amido-C6-NH2 TFA

DMSO:105.5 mg/mL (193.76 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years