AG6033是一种潜在的新型CRBN调节剂。AG6033通过调控CRBN与多种抗肿瘤靶蛋白的相互作用抑制多种肿瘤细胞。AG6033可引起GSPT1和IKZF1的降解，且AG6033诱导CRBN依赖的细胞毒性作用。

AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN -dependent cytotoxic effect [1].

AG6033 (0.064-40 μM, 4 h) has potent inhibition ability against A549 [1]. AG6033 (1-10 μM, 24 h) significantly promotes apoptosis of A549 cells in a dose-dependent manner [1]. Cell Proliferation Assay Cell Line: A549 cells [1] Concentration: 0.064 μM, 0.32 μM, 1.6 μM, 8 μM, and 40 μM Incubation Time: 4 h Result: Exhibited potent inhibitory ability against A549, with an IC 50 of 0.853 μM. Apoptosis Analysis Cell Line: A549 cells [1] Concentration: 1 μM, 5 μM, 10 μM Incubation Time: 24 h Result: Significantly promoted apoptosis of A549 cells in a dose-dependent manner, and the proportion of late apoptotic cells were 5.39%, 22.0%, and 29.1%, respectively.

329706-62-9

C30H23N5O4

517.53

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years