ALV1 是一种有效的Ikaros和Helios降解剂。ALV1 能显著降低 IKZF1-4、CK1α (酪蛋白激酶 1α，CSNK1A1) 和核糖体蛋白 RPL4 的蛋白丰度。ALV1 对和 IKZF1/2/3 表现出相似的降解活性。ALV1 诱导 Helios/CRBN 二聚反应。ALV1 在很大程度上促进了 IL-2 的分泌。

ALV1 is a potent Ikaros and Helios degrader. ALV1 potently reduces the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4. ALV1 shows similar degradation activity towards IKZF1/2/3. ALV1 induced Helios/CRBN dimerization. ALV1 promoted IL-2 secretion to a great extent [1].

2438124-79-7

C25H23ClN4O5

494.93

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years