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Pitstop 2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pitstop 2图片
CAS NO:1419320-73-2
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Pitstop2 是一种选择性的两性蛋白结合的网格蛋白末端结构域抑制剂,IC50 值为 12 μM。 Pitstop2 严重干扰受体介导的内吞作用、HIV 进入和突触小泡循环。

产品描述

Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle recycling.

体外活性

Pitstop2 potently and specifically reduced HIV-1 infectivity by >90% in HeLa cells. Preincubation of HeLa cells with Pitstop2 (Pitstops 2) leads to a dose-dependent inhibition of Tf uptake with an IC50 value (12-5 μM). Application of 30 μM Pitstop2 completely blocked Tf endocytosis. Pitstop2-induced block of Tf endocytosis in HeLa cells was completely reversed within 1-3 hr of drug washout. In U2OS cells, the IC50 for Tf uptake is 9.7 μM. Pitstop 2 also causes a potent inhibition of EGF uptake[1].

Cas No.

1419320-73-2

分子式

C20H13BrN2O3S2

分子量

473.36

别名

Pitstop 2

储存和溶解度

DMSO:62.5 mg/mL (132.03 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years