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Diatrizoic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diatrizoic Acid图片
CAS NO:117-96-4
包装:500 mg
市场价:480元

产品名称
Diatrizoate
泛影酸
Amidotrizoic acid
产品介绍
Diatrizoic acid 是一种有机碘化不透射线 X 射线造影剂,用于放射诊断,具有对气道进行放射照相成像的潜力。它通过钙失调诱导线粒体更新和氧化应激,激活细胞凋亡。

产品描述

Diatrizoic Acid is an organic, iodinated radiopaque X-ray contrast medium used in diagnostic radiography.

激酶实验

Radiochemical enzyme assays for COX-1 and COX-2: 10 μL of purified COX-1 (0.7-0.8 μg) or COX-2 (3.0 units, 0.3μg) is activated with 50 μL of cofactor solution [l-epinephrine (1.3 mg/mL), reduced glutathione (0.3 mg/mL), and hematin (1.3 mg/mL) in oxygen-free Tris-HCl buffer (pH 8.0)]. The enzyme solution (60 μL) is added to Ibuprofen solutions or DMSO (20 μL) after [14C]arachidonic acid is added in 0.2 mL eight-strip test tubes and preincubated 10 minutes on ice. Samples are incubated for 15 minutes at 37 °C, after which the reaction is terminated by addition of 10 μL of 2 M HCl and 5 μL of carrier solution (PGE2 and PGF2α, 0.2 μg/mL of each in EtOH). The unmetabolized arachidonic acid is separated from the prostaglandin products by column chromatography and eluted with n-hexane-dioxane-glacial acetic acid (70:30:1). The prostaglandin products are then eluted with EtOAc-MeOH (85:15), and the samples are counted in a Packard scintillation spectrometer. IC50 values are obtained by linear regression analysis.

Cas No.

117-96-4

分子式

C11H9I3N2O4

分子量

613.916

别名

Diatrizoate;泛影酸;Amidotrizoic acid;Diatrizoic Acid

储存和溶解度

DMSO:40 mg/mL (65.16 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years