CDK8-IN-6 (compound 9) 是一种有效的细胞周期蛋白依赖性激酶8 (CDK8)抑制剂，Kd为 13 nM。CDK8-IN-6 对 MOLM-13、OCI-AML3、MV4-11、NRK 和 H9c2 细胞具有细胞毒性，IC50s 分别为 11.2、7.5、8.6、20.5、12.5-25 μM。CDK8-IN-6 具有研究 AML 癌症的潜力。

CDK8-IN-6 (compound 9) is a potent cyclin-dependent kinase 8 (CDK8) inhibitor with an K d of 13 nM. CDK8-IN-6 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC 50 s of 11.2, 7.5, 8.6, 20.5, 12.5-25 μM, respectively. CDK8-IN-6 has the potential for the research of AML-cancer [1].

2415156-27-1

C26H37ClN2

413.04

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years