ME1111 is an inhibitor of the succinate dehydrogenase of Trichophyton species and it also is an antifungal agent that is active against dermatophytes. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research.

ME1111 mainly affects the permeability of the cell membrane[1]. ME1111 inhibits T. mentagrophytes TIMM 2789 (MICs: 0.5 μg/mL and 0.25 μg/mL in RPMI 1640 medium and SDB, respectively). ME1111 strongly inhibits the succinate-2,6-dichlorophenolindophenol reductase reaction in Trichophyton rubrum and T. mentagrophytes (IC50: 0.029 μg/mL, 0.025 μg/mL) but only shows moderate inhibition of the same reaction in human cell lines[2].

1391758-52-3

C12H14N2O

202.25

ME1111

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years