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Cobaltic Protoporphyrin IX(chloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:102601-60-5
包装:500 mg
市场价:9409元

产品名称
Cobaltic Protoporphyrin IX (chloride)
产品介绍

产品描述

Cobaltic protoporphyrin IX is a metalloporphyrin and an inducer of heme oxygenase-1 (HO-1) activity.1Unlike other metalloporphyrins, cobaltic protoporphyrin IX induces activity of HO-1, the rate-limiting enzyme in heme catabolism,in vitroandin vivo.1,2It also reduces the activity of δ-aminolevulinate synthase, the enzyme that catalyzes the rate-limiting step of heme biosynthesis, as well as decreases the activity of cytochrome P450 (CYP), in rat liver microsomesex vivowhen administered at a dose of 125 μmol/kg.2Cobaltic protoporphyrin IX (5 mg/kg) prevents liver injury and increases in the percentage of hepatic apoptotic cells in a mouse model of liver ischemia-reperfusion injury.3It increases survival and decreases the number of lung colony forming units (CFUs) in mice infected withY. pestisat the same dose.4Cobaltic protoporphyrin IX has also been used as a catalyst for the electrochemical reduction of carbon dioxide in carbon electrodes.5

Cas No.

102601-60-5

分子式

C34H32ClCoN4O4

分子量

655.03

别名

Cobaltic Protoporphyrin IX (chloride)

储存和溶解度

Ethanol:1 mg/mL
DMSO:25 mg/mL
DMF:PBS (pH 7.2) (1:6):0.14 mg/mL
DMF:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years