JI051,Anti-cancer activity. is a stabilizer for the Hes1-PHB2 interaction, interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1.

JI051 (0.1-10 μM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM.JI051 causes G2/M cell-cycle arrest.

2234281-75-3

C22H24N2O3

364.44

JI051

DMSO:125 mg/mL (342.99 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years