Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.

1962925-29-6

C27H43Br2F2N5O

651.47

Nirogacestat dihydrobromide

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years