Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM, respectively).3

103106-24-7

C25H30Cl2O5

481.41

Napyradiomycin A1;Napyradiomycin A1

DMSO:Soluble
Methanol:Soluble
Ethanol:Soluble
Dichloromethane:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years