PF-5274857 is a potent, orally active and selective inhibitor of hedgehog (Hh) signaling pathway (IC50 = 5.8 nM, Ki = 4.6 nM) . PF-5274857 effectively penetrates the blood-brain barrier and inhibits Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates.

T28388

C21H29ClN4O6S2

533.06

PF-5274857;PF-5274857 mseylate;PF5274857 HCl;PF-5274857 mesylate;PF 5274857;PF-5274857 mseylate (1373615-35-0 free base)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years