CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].

CDK9: 17 μM (IC50, MCF-7 cells)

CDK9 Antagonist-1;CDK9 Antagonist-1

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years