CRANAD 2 是一种特异性近红外 (NIR) 荧光探针，可用于检测 Aβ 斑块。它可透过血脑屏障，且对Aβ 聚集体有高亲和性，其Kd=38 nM。

CRANAD-2 is a difluoroboron-derivatized curcumins as near-infrared probe for in vivo detection of amyloid-beta deposits. Upon interacting with Abeta aggregates, CRANAD-2 undergoes a range of changes, which include a 70-fold fluorescence intensity increase, a 90 nm blue shift (from 805 to 715 nm), and a large increase in quantum yield.

1193447-34-5

C23H25BF2N2O2

410.27

CRANAD 2

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years