CHIR98014 is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50s: 0.65 and 0.58 nM). Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50: 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals.

T3074L

C20H19Cl4N9O2

559.23

CHIR-98014 hydrochloride;CHIR98014 HCl;CHIR 98014;CHIR98014;CHIR-98014;CT-98014;CHIR98014 HCl (252935-94-7 free base)

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years