HSD1590 is potent ROCK inhibitor, with IC 50 s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K d s<2 nM). HSD1590 displays low cytotoxicity.

HSD1590 (0.5-1 μM; 24 hours) exhibits an impressive attenuation in migration[1]. HSD1590 (0.5-10 μM; 12-24 horus) shows that the excellent migration inhibition observed is not due to cell death, but inhibition of live cell migration[1]. Cell Viability Assay[1]Cell Line: MDA-MB-23 cells Concentration: 0.5-10 μM Incubation Time: 12-24 hours Result: Exhibited approximately 80% viability at 12 hours and yielded an overall viability of 63% at 24 h.

2379279-96-4

C20H18BN3O3

359.19

HSD1590

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years