COX-2-IN-10 是一种有效的COX-2抑制剂。COX-2-IN-10 以浓度依赖性方式抑制 PGE2的产生 (IC50=2.54 μM)。COX-2-IN-10 在 mRNA 和蛋白水平上抑制iNOS和COX-2的表达。COX-2-IN-10 抑制 IL-6、TNF-α 和 IL-1β 的产生。

COX-2-IN-10 is a potent COX-2 inhibitor. COX-2-IN-10 inhibits the production of PGE 2 in concentration dependent manner (IC 50 =2.54 μM). COX-2-IN-10 inhibits the expression of iNOS and COX-2 on mRNA and protein level. COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β [1].

COX-2-IN-10 (compound 9k) (10 μM, 24 h) exhibits high safety and did not show any significant cytotoxicity over LPS-Induced RAW264.7 macrophage cells [1]. COX-2-IN-10 (0.4, 2, 10 μM) inhibits the production of PGE 2 in concentration dependent manner in RAW264.7 macrophage cells (IC 50 =2.54 μM) [1]. COX-2-IN-10 (2.5, 5, 10 μM) significantly inhibits the mRNA expression of iNOS and COX-2 at 10 μM [1]. COX-2-IN-10 (2.5, 5, 10 μM) significantly inhibits iNOS and COX-2 protein level starting from 10 μM concentration [1]. COX-2-IN-10 (2.5, 5, 10 μM; 1 h) inhibits the production of IL-6, TNF-α and IL-1β [1]. Cell Viability Assay [1] Cell Line: RAW264.7 macrophage cells Concentration: 10 μM Incubation Time: 24 h Result: Exhibited high safety and did not show any significant cytotoxicity over LPS-Induced RAW264.7 macrophage cells. RT-PCR [1] Cell Line: RAW264.7 macrophage cells Concentration: 2.5, 5, 10 μM Incubation Time: Result: Inhibits the mRNA expression of iNOS and COX-2 at 10 μM. Western Blot Analysis [1] Cell Line: RAW264.7 macrophage cells Concentration: 2.5, 5, 10 μM Incubation Time: Result: Significantly inhibited iNOS and COX-2 protein level starting from 10 μM concentration.

C31H32FN5O2S

557.68

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years