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Loxoprofen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Loxoprofen图片
CAS NO:68767-14-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Loxoprofeno
洛索洛芬
Koloxo
Loxoprofene
产品介绍
Loxoprofen 是一种非甾体类抗炎药,具有解热作用,可用于缓解疼痛的研究。它是非选择性COX抑制剂,对 COX-1 和 COX-2 的IC50分别为 6.5 和 13.5 μM。

产品描述

Loxoprofen is an anti-inflammatory non-steroidal medicine.

体外活性

Loxoprofen sodium(LOX) does not affect the proliferation and viability of LLC cells in vitro. HUVECs treated with LOX results in the inhibition of the tubular formation. Treatment with 50 mg/ml LOX reveals a 33% decline in in vitro angiogenesis, compared with vehicle-treated HUVECs. This inhibition is presumably due to inhibition of VEGF activity[1].

体内活性

Loxoprofen sodium (LOX), inhibits in vivo growth of implanted Lewis lung carcinoma (LLC). Intratumoral vessel density in LOX-treated mice is significantly lower than that of mice without treatment. Intratumoral expressions of vascular endothelial growth factor (VEGF) mRNA are attenuated by the LOX treatment. LOX suppresses both intratumoral and systemic VEGF protein in LLC-implanted mice. LOX also inhibits tubular formation of primary cultured human umbilical vein endothelial cells, presumably due to the inhibition of VEGF. In patients with advanced non-small cell lung cancer, LOX medication (120 mg/day) for a week significantly decreases the plasma VEGF level[1].

细胞实验

To determine the proliferation of LLC cells with or without Loxoprofen, 2×104 cells are seeded into 100-mm dishes containing 10 ml culture medium supplemented with 50 μg/ml Loxoprofen or vehicle on day 0. On days 2, 3, 4 and 6, the cells are trypsinized and counted. (Only for Reference)

Cas No.

68767-14-6

分子式

C15H18O3

分子量

246.306

别名

Loxoprofeno;洛索洛芬;Koloxo;Loxoprofene;Loxoprofen

储存和溶解度

H2O:<1 mgml
DMSO:46 mg/mL (186.8 mM)
Ethanol:46 mg/mL (186.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years