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CGP48369
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CGP48369图片
CAS NO:135689-23-5
包装:5 mg
市场价:7000元

产品介绍

产品描述

CGP48369 is a nonpeptidic antagonist of the angiotensin II receptor. It is used for anti-hypertensive research.

体外活性

CGP 48369 inhibits AII-induced contraction in rabbit aorta (IC50: 8.7 nM). CGP 48369 binds to the ATl receptor (IC50: 1.8 nM in vascular smooth muscle cells) [1].

体内活性

CGP48369 (10 mg/kg/day p.o.) decreases BP in two-kidney/one-clip renal hypertensive rats for at least 24 h. All evoked significantly smaller contractions in SHR treated with CGP 48369 than in the other treated SHR. Whereas maximal response in CGP 48369-treated SHR and in nifedipine treated SHR is slightly greater as compared with that in WKY [1]. In SHR, antihypertensive therapy with either benazepril HCl, CGP 48369, valsartan, or nifedipine (each 10 mg/kg/d for 8 weeks) significantly increase endothelium-dependent relaxations evoked by acetylcholine [2].

Cas No.

135689-23-5

分子式

C26H30N6O

分子量

442.56

别名

CGP48369

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years