CGP48369 is a nonpeptidic antagonist of the angiotensin II receptor. It is used for anti-hypertensive research.

CGP 48369 inhibits AII-induced contraction in rabbit aorta (IC50: 8.7 nM). CGP 48369 binds to the ATl receptor (IC50: 1.8 nM in vascular smooth muscle cells) [1].

CGP48369 (10 mg/kg/day p.o.) decreases BP in two-kidney/one-clip renal hypertensive rats for at least 24 h. All evoked significantly smaller contractions in SHR treated with CGP 48369 than in the other treated SHR. Whereas maximal response in CGP 48369-treated SHR and in nifedipine treated SHR is slightly greater as compared with that in WKY [1]. In SHR, antihypertensive therapy with either benazepril HCl, CGP 48369, valsartan, or nifedipine (each 10 mg/kg/d for 8 weeks) significantly increase endothelium-dependent relaxations evoked by acetylcholine [2].

135689-23-5

C26H30N6O

442.56

CGP48369

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years