BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC 50 of 7.68 nM. BMSpep-57 binds to PD-L1 with K d s of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs.

In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300?nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC 50 of 7.68?nM[1].BMSpep-57 induced high levels of IL-2 at 1?μM and 500?nM concentrations in ?SEB-stimulated peripheral blood mononuclear cells[1].BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested[1].

1629655-80-6

C89H126N24O19S

1868.2

BMSpep-57

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years